In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a magically expanded briefcase, which houses a number of dangerous creatures and their habitats. When the creatures escape from the briefcase, it sends the American wizarding authorities after Newt, and threatens to strain even further the state of magical and non-magical relations.

An embarrassing video of Anthony surfaces online right before his fifth high school reunion. The Smosh dudes then race to pull down the clip before it blows Anthony's chances of reconnecting with his teen crush Anna.